IDI1 - Isopentenyl-diphosphate Delta-isomerase 1 - human protein (Function)
 
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IDI1 »  Isopentenyl-diphosphate Delta-isomerase 1   [ EC 5.3.3.2 ]
 
Protein also known as:  Isopentenyl pyrophosphate isomerase 1 (IPPI1).
Gene name:  IDI1
Family name: IPP isomerase type 1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 2
GENE REF ISO

Function

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Overview 
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  
1
  • CuratedUniProtKB
GO molecular function 
Hydrolase activitydefinition[GO:0016787] silver  
  • IEAInterPro 2 GO
Isopentenyl-diphosphate delta-isomerase activitydefinition[GO:0004452]  
1
  • IDAUniProtKB
  • IEAEC 2 GO
Isoform  Iso 1   Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Isoform  Iso 1   Manganese ion bindingdefinition[GO:0030145]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Dimethylallyl diphosphate biosynthetic processdefinition[GO:0050992]  
  • IEAUniPathway
Isoprenoid biosynthetic processdefinition[GO:0008299]  
1
  • IDAUniProtKB
  • IEAUniProtKB KW
Response to stilbenoiddefinition[GO:0035634] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.3.2: Isopentenyl diphosphate dimethylallyl diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+3422  
Terpenoid backbone biosynthesis  hsa00900+3422  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
Cholesterol biosynthesis  REACT_9405  
 
More information is available from:
 

Keywords

Biological process 
Cholesterol biosynthesis  definition   [KW-0152]
Cholesterol metabolism  definition   [KW-0153]
Isoprene biosynthesis  definition   [KW-0414]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q13907
Other
GenomeRNAi: 3422
PRO: PR:Q13907
Chemistry
GuidetoPHARMACOLOGY: 646