CACNA1C - Voltage-dependent L-type calcium channel subunit alpha-1C - human protein (Function)
 
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CACNA1C »  Voltage-dependent L-type calcium channel subunit alpha-1C
 
Protein also known as:  Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle.
Gene name:  CACNA1C
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.  
6
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.11.4  
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • IPIBHF-UCL
Calmodulin bindingdefinition[GO:0005516]  
1
  • IPIUniProtKB
Contributes to high voltage-gated calcium channel activitydefinition[GO:0008331]  
1
  • TASBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245]  
2
  • IDAUniProtKB
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Calcium ion transport into cytosoldefinition[GO:0060402]  
1
  • TASBHF-UCL
Calcium ion-dependent exocytosisdefinition[GO:0017156] silver  
  • IEAOrtholog Compara
Calcium-mediated signaling using extracellular calcium sourcedefinition[GO:0035585]  
1
  • TASBHF-UCL
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • TASBHF-UCL
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Growth hormone secretiondefinition[GO:0030252] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
1
  • TASBHF-UCL
Regulation of organ growthdefinition[GO:0046620] silver  
  • IEAOrtholog Compara
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAOrtholog Compara
Smooth muscle contraction involved in micturitiondefinition[GO:0060083] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+775  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+775  
Calcium signaling pathway  hsa04020+775  
Cardiac muscle contraction  hsa04260+775  
Cholinergic synapse  hsa04725+775  
Dilated cardiomyopathy  hsa05414+775  
Dopaminergic synapse  hsa04728+775  
GABAergic synapse  hsa04727+775  
Glutamatergic synapse  hsa04724+775  
GnRH signaling pathway  hsa04912+775  
Hypertrophic cardiomyopathy (HCM)  hsa05410+775  
Long-term potentiation  hsa04720+775  
MAPK signaling pathway  hsa04010+775  
Type II diabetes mellitus  hsa04930+775  
Vascular smooth muscle contraction  hsa04270+775  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cav1.2
GenomeRNAi: 775
PRO: PR:Q13936
Chemistry
GuidetoPHARMACOLOGY: 529