RUNX2 - Runt-related transcription factor 2 - human protein (Function)
 
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References

 
RUNX2 »  Runt-related transcription factor 2
 
Protein also known as:  Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A).
Gene name:  RUNX2
Entry whose protein(s) existence is based on evidence at protein level
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1 60 3
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
1
  • InterPro 2 GO
bHLH transcription factor bindingdefinition[GO:0043425] silver  
1
  • Ortholog Compara
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Repressing transcription factor bindingdefinition[GO:0070491] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • Ortholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212] silver  
1
  • Ortholog Compara
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
1
  • Ortholog Curator
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • Ortholog Curator
Chondrocyte developmentdefinition[GO:0002063] silver  
1
  • Ortholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
1
  • Ortholog Compara
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
1
  • Ortholog Compara
Endochondral ossificationdefinition[GO:0001958] silver  
1
  • Ortholog Compara
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Ossificationdefinition[GO:0001503]  
1
  • UniProtKB
Osteoblast developmentdefinition[GO:0002076] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
2
  • UniProtKB
Osteoblast fate commitmentdefinition[GO:0002051] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of chondrocyte differentiationdefinition[GO:0032332] silver  
1
  • Ortholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusdefinition[GO:1901522]  
1
  • Ortholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040036] silver  
1
  • Ortholog Compara
Regulation of odontogenesis of dentin-containing toothdefinition[GO:0042487] silver  
1
  • Ortholog Compara
Stem cell differentiationdefinition[GO:0048863] silver  
1
  • Ortholog Compara
T cell differentiationdefinition[GO:0030217] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RUNX2
GenomeRNAi: 860
PRO: PR:Q13950