RUNX2 - Runt-related transcription factor 2 - human protein (Function)
 
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References

 
RUNX2 »  Runt-related transcription factor 2
 
Protein also known as:  Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A).
Gene name:  RUNX2
Entry whose protein(s) existence is based on evidence at protein level
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1 54 3
GENE REF ISO

Function

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Overview 
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
bHLH transcription factor bindingdefinition[GO:0043425] silver  
  • IEAOrtholog Compara
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Repressing transcription factor bindingdefinition[GO:0070491] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASPINC
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
  • ISSOrtholog Curator
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cellular response to BMP stimulusdefinition[GO:0071773]  
  • ISSOrtholog Curator
Chondrocyte developmentdefinition[GO:0002063] silver  
  • IEAOrtholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
  • IEAOrtholog Compara
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
  • IEAOrtholog Compara
Endochondral ossificationdefinition[GO:0001958] silver  
  • IEAOrtholog Compara
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503]  
1
  • TASUniProtKB
Osteoblast developmentdefinition[GO:0002076] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
2
  • IEPUniProtKB
Osteoblast fate commitmentdefinition[GO:0002051] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of chondrocyte differentiationdefinition[GO:0032332] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusdefinition[GO:1901522]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040036] silver  
  • IEAOrtholog Compara
Regulation of odontogenesis of dentin-containing toothdefinition[GO:0042487] silver  
  • IEAOrtholog Compara
Stem cell differentiationdefinition[GO:0048863] silver  
  • IEAOrtholog Compara
T cell differentiationdefinition[GO:0030217] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RUNX2
GenomeRNAi: 860
PRO: PR:Q13950