CBFB - Core-binding factor subunit beta - human protein (Function)
 
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Gene
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CBFB »  Core-binding factor subunit beta  (CBF-beta)
 
Protein also known as:  Polyomavirus enhancer-binding protein 2 beta subunit (PEA2-beta).
Gene name:  CBFB
Family name: CBF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 65 2
GENE REF ISO

Function

 show evidences
Overview 
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • PINC
Transcription coactivator activitydefinition[GO:0003713] silver  
1
  • InterPro 2 GO
GO biological process 
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Definitive hemopoiesisdefinition[GO:0060216] silver  
1
  • Ortholog Compara
Lymphocyte differentiationdefinition[GO:0030098] silver  
1
  • Ortholog Compara
Myeloid cell differentiationdefinition[GO:0030099] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Protein polyubiquitinationdefinition[GO:0000209] silver  
1
  • CACAO
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CBFB
GenomeRNAi: 865
PRO: PR:Q13951