CBFB - Core-binding factor subunit beta - human protein (Function)
 
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CBFB »  Core-binding factor subunit beta  (CBF-beta)
 
Protein also known as:  Polyomavirus enhancer-binding protein 2 beta subunit (PEA2-beta).
Gene name:  CBFB
Family name: CBF-beta
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 2
GENE REF ISO

Function

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Overview 
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Transcription coactivator activitydefinition[GO:0003713] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Definitive hemopoiesisdefinition[GO:0060216] silver  
  • IEAOrtholog Compara
Lymphocyte differentiationdefinition[GO:0030098] silver  
  • IEAOrtholog Compara
Myeloid cell differentiationdefinition[GO:0030099] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CBFB
GenomeRNAi: 865
PRO: PR:Q13951