CDK13 - Cyclin-dependent kinase 13 - human protein (Function)
 
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CDK13 »  Cyclin-dependent kinase 13   [ EC 2.7.11.22EC 2.7.11.23 ]
 
Protein also known as:  Cholinesterase-related cell division controller.
Gene name:  CDK13
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cyclin bindingdefinition[GO:0030332]  
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  • IPIMGI
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
  • IEAEC 2 GO
Isoform  Iso 2   Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
1
  • IDAUniProtKB
GO biological process 
Alternative mRNA splicing, via spliceosomedefinition[GO:0000380]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Hemopoiesisdefinition[GO:0030097]  
1
  • IMPUniProtKB
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Phosphorylation of RNA polymerase II C-terminal domaindefinition[GO:0070816]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Regulation of mitosisdefinition[GO:0007088]  
1
  • TASPINC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.23: ATP + [DNA-directed RNA polymerase] ADP + [DNA-directed RNA polymerase] phosphate.  
1
  • CuratedUniProtKB
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CDC2L5
GenomeRNAi: 8621
PRO: PR:Q14004
Chemistry
GuidetoPHARMACOLOGY: 1966