CAMK1 - Calcium/calmodulin-dependent protein kinase type 1 - human protein (Function)
 
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CAMK1 »  Calcium/calmodulin-dependent protein kinase type 1   [ EC 2.7.11.17 ]
 
Protein also known as:  CaM kinase I alpha (CaMKI-alpha).
Gene name:  CAMK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Nucleocytoplasmic transportdefinition[GO:0006913] silver  
  • IEAOrtholog Compara
Positive regulation of dendritic spine developmentdefinition[GO:0060999]  
1
  • IMPUniProtKB
Positive regulation of muscle cell differentiationdefinition[GO:0051149]  
1
  • IMPBHF-UCL
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • IDAUniProtKB
Positive regulation of protein export from nucleusdefinition[GO:0046827] silver  
  • IEAOrtholog Compara
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902]  
1
  • IDAUniProtKB
Positive regulation of synapse structural plasticitydefinition[GO:0051835]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of muscle cell differentiationdefinition[GO:0051147]  
1
  • IDAUniProtKB
Regulation of protein bindingdefinition[GO:0043393]  
1
  • IDAUniProtKB
Regulation of protein localizationdefinition[GO:0032880]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.17: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca(2+)/calmodulin activation.  
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  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CAMK1
GenomeRNAi: 8536
PRO: PR:Q14012
Chemistry
GuidetoPHARMACOLOGY: 1952