IL18 - Interleukin-18 - human protein (Function)
 
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IL18 »  Interleukin-18  (IL-18)
 
Protein also known as:  Interferon gamma-inducing factor (IFN-gamma-inducing factor).
Gene name:  IL18
Family name: IL-1
Entry whose protein(s) existence is based on evidence at protein level
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1 520 2
GENE REF ISO

Function

 show evidences
Overview 
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • TASUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • IDAUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • IDAUniProtKB
Chemokine biosynthetic processdefinition[GO:0042033]  
1
  • TASUniProtKB
Granulocyte macrophage colony-stimulating factor biosynthetic processdefinition[GO:0042253]  
1
  • TASUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
1
  • IDAUniProtKB
Interferon-gamma biosynthetic processdefinition[GO:0042095]  
1
  • TASUniProtKB
Interleukin-13 biosynthetic processdefinition[GO:0042231]  
1
  • TASUniProtKB
Interleukin-2 biosynthetic processdefinition[GO:0042094]  
1
  • TASUniProtKB
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • IDAUniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • IMPUniProtKB
Natural killer cell activationdefinition[GO:0030101] silver  
  • IEAOrtholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
2
  • IDAUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of granulocyte macrophage colony-stimulating factor productiondefinition[GO:0032725]  
1
  • IDABHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ICBHF-UCL
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
2
  • IDABHF-UCL
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
1
  • IDABHF-UCL
Positive regulation of natural killer cell proliferationdefinition[GO:0032819]  
1
  • IDABHF-UCL
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346] silver  
  • IEAOrtholog Compara
Positive regulation of NK T cell proliferationdefinition[GO:0051142]  
1
  • IDABHF-UCL
Positive regulation of tissue remodelingdefinition[GO:0034105]  
1
  • ICBHF-UCL
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • IDAUniProtKB
Sleepdefinition[GO:0030431]  
1
  • ISSUniProtKB
T-helper 1 type immune responsedefinition[GO:0042088]  
1
  • IDAUniProtKB
Type 2 immune responsedefinition[GO:0042092]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3606  
Cytokine-cytokine receptor interaction  hsa04060+3606  
Cytosolic DNA-sensing pathway  hsa04623+3606  
Influenza A  hsa05164+3606  
Legionellosis  hsa05134+3606  
Malaria  hsa05144+3606  
NOD-like receptor signaling pathway  hsa04621+3606  
Rheumatoid arthritis  hsa05323+3606  
Salmonella infection  hsa05132+3606  
Tuberculosis  hsa05152+3606  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_18
GenomeRNAi: 3606
PRO: PR:Q14116