DAG1 - Dystroglycan - human protein (Function)
 
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DAG1 »  Dystroglycan
 
Protein also known as:  Dystrophin-associated glycoprotein 1. Cleaved into:  Alpha-dystroglycan; Beta-dystroglycan.
Gene name:  DAG1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.  
4
  • CuratedUniProtKB
Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.  
4
  • CuratedUniProtKB
Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.  
4
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • IDAUniProtKB
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Dystroglycan bindingdefinition[GO:0002162] silver  
  • IEAOrtholog Compara
Laminin-1 bindingdefinition[GO:0043237]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
SH2 domain bindingdefinition[GO:0042169]  
1
  • IDAUniProtKB
Structural constituent of muscledefinition[GO:0008307]  
1
  • IMPUniProtKB
Tubulin bindingdefinition[GO:0015631]  
1
  • IDAUniProtKB
Vinculin bindingdefinition[GO:0017166]  
1
  • IPIUniProtKB
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
Basement membrane organizationdefinition[GO:0071711] silver  
  • IEAOrtholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Calcium-dependent cell-matrix adhesiondefinition[GO:0016340] silver  
  • IEAOrtholog Compara
Commissural neuron axon guidancedefinition[GO:0071679] silver  
  • IEAOrtholog Compara
Cytoskeletal anchoring at plasma membranedefinition[GO:0007016]  
1
  • IMPUniProtKB
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
  • IEAOrtholog Compara
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • IDAUniProtKB
Microtubule anchoringdefinition[GO:0034453]  
1
  • IMPUniProtKB
Modulation by virus of host morphology or physiologydefinition[GO:0019048]  
1
  • IDAUniProtKB
Morphogenesis of an epithelial sheetdefinition[GO:0002011] silver  
  • IEAOrtholog Compara
Myelination in peripheral nervous systemdefinition[GO:0022011] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPUniProtKB
Negative regulation of MAPK cascadedefinition[GO:0043409]  
1
  • IMPUniProtKB
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • IMPUniProtKB
Nerve maturationdefinition[GO:0021682] silver  
  • IEAOrtholog Compara
NLS-bearing protein import into nucleusdefinition[GO:0006607]  
1
  • IDAUniProtKB
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+1605  
Dilated cardiomyopathy  hsa05414+1605  
ECM-receptor interaction  hsa04512+1605  
Hypertrophic cardiomyopathy (HCM)  hsa05410+1605  
Viral myocarditis  hsa05416+1605  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dystroglycan
GenomeRNAi: 1605
PRO: PR:Q14118