SERTAD2 - SERTA domain-containing protein 2 - human protein (Function)
 
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Protein
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References

 
SERTAD2 »  SERTA domain-containing protein 2
 
Protein also known as:  Transcriptional regulator interacting with the PHD-bromodomain 2 (TRIP-Br2).
Gene name:  SERTAD2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.  
1
  • CuratedUniProtKB
GO molecular function 
Transcription coactivator activitydefinition[GO:0003713] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9792
PRO: PR:Q14140