EIF3A - Eukaryotic translation initiation factor 3 subunit A - human protein (Function)
 
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EIF3A »  Eukaryotic translation initiation factor 3 subunit A  (eIF3a)
 
Protein also known as:  Eukaryotic translation initiation factor 3 subunit 10.
Gene name:  EIF3A
Family name: eIF-3 subunit A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 77 1
GENE REF ISO

Function

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Overview 
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  
1
  • CuratedUniProtKB
GO molecular function 
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Structural molecule activitydefinition[GO:0005198]  
1
  • NASUniProtKB
Contributes to translation initiation factor activitydefinition[GO:0003743]  
3
  • ICUniProtKB
GO biological process 
Formation of translation initiation complexdefinition[GO:0001732]  
1
  • IDAUniProtKB
Formation of translation preinitiation complexdefinition[GO:0001731]  
  • IEAUniProtKB Annot
Regulation of translational initiationdefinition[GO:0006446]  
  • IEAUniProtKB Annot
Translational initiationdefinition[GO:0006413]  
2
  • ICUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA transport  hsa03013+8661  
According to Reactome, this protein belongs to the following pathways:
3' -UTR-mediated translational regulation  REACT_1762  
Gene Expression  REACT_71  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Initiation factor  definition   [KW-0396]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EIF3A
GenomeRNAi: 8661
PRO: PR:Q14152