ARHGEF7 - Rho guanine nucleotide exchange factor 7 - human protein (Function)
 
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Protein
Gene
References

 
ARHGEF7 »  Rho guanine nucleotide exchange factor 7
 
Protein also known as:  PAK-interacting exchange factor beta.
Gene name:  ARHGEF7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 6
GENE REF ISO

Function

 show evidences
Overview 
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.  
3
  • CuratedUniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Lamellipodium assemblydefinition[GO:0030032]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
  • IEAUniProtKB KW
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IMPUniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of actin cytoskeleton  hsa04810+8874  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF7
GenomeRNAi: 8874
PRO: PR:Q14155