ARHGEF7 - Rho guanine nucleotide exchange factor 7 - human protein (Function)
 
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ARHGEF7 »  Rho guanine nucleotide exchange factor 7
 
Protein also known as:  PAK-interacting exchange factor beta.
Gene name:  ARHGEF7
Entry whose protein(s) existence is based on evidence at protein level
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1 113 6
GENE REF ISO

Function

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Overview 
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.  
4
  • UniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
21
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
1
  • InterPro 2 GO
GO biological process 
Astrocyte cell migrationdefinition[GO:0043615] silver  
1
  • Ortholog Compara
Focal adhesion assemblydefinition[GO:0048041]  
1
  • UniProtKB
Golgi organizationdefinition[GO:0007030]  
1
  • ParkinsonsUK-UCL
Hematopoietic progenitor cell differentiationdefinition[GO:0002244] silver  
1
  • Ortholog Compara
Lamellipodium assemblydefinition[GO:0030032]  
1
  • Ortholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of fibroblast migrationdefinition[GO:0010763]  
1
  • UniProtKB
Positive regulation of growth hormone secretiondefinition[GO:0060124] silver  
1
  • Ortholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • UniProtKB
  • BHF-UCL
Positive regulation of lamellipodium morphogenesisdefinition[GO:2000394]  
1
  • UniProtKB
Positive regulation of protein bindingdefinition[GO:0032092] silver  
1
  • Ortholog Compara
Positive regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900026]  
1
  • UniProtKB
Regulation of GTP bindingdefinition[GO:1904424]  
1
  • ParkinsonsUK-UCL
Regulation of Rho protein signal transductiondefinition[GO:0035023] silver  
1
  • InterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of actin cytoskeleton  hsa04810+8874  
According to Reactome, this protein belongs to the following pathways:
EGFR downregulation  R-HSA-182971  
Ephrin signaling  R-HSA-3928664  
G alpha (12/13) signalling events  R-HSA-416482  
NRAGE signals death through JNK  R-HSA-193648  
Rho GTPase cycle  R-HSA-194840  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF7
GenomeRNAi: 8874
PRO: PR:Q14155