SCRIB - Protein scribble homolog - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SCRIB »  Protein scribble homolog  (Scribble)
 
Protein also known as:  Protein LAP4.
Gene name:  SCRIB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 92 3
GENE REF ISO

Function

 show evidences
Overview 
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.  
8
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
  • BHF-UCL
GO biological process 
Activation of GTPase activitydefinition[GO:0090630]  
1
  • UniProtKB
Apoptotic process involved in morphogenesisdefinition[GO:0060561]  
1
  • UniProtKB
Astrocyte cell migrationdefinition[GO:0043615] silver  
1
  • Ortholog Compara
Asymmetric protein localizationdefinition[GO:0008105] silver  
1
  • Ortholog Compara
Auditory receptor cell stereocilium organizationdefinition[GO:0060088] silver  
1
  • Ortholog Compara
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Cochlear nucleus developmentdefinition[GO:0021747] silver  
1
  • Ortholog Compara
Establishment of apical/basal cell polaritydefinition[GO:0035089]  
1
  • UniProtKB
Mammary gland duct morphogenesisdefinition[GO:0060603]  
1
  • Ortholog Curator
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • UniProtKB
Neural tube closuredefinition[GO:0001843]  
1
  • UniProtKB
Positive chemotaxisdefinition[GO:0050918]  
1
  • UniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of receptor recyclingdefinition[GO:0001921]  
1
  • UniProtKB
Protein localization to adherens junctiondefinition[GO:0071896]  
1
  • BHF-UCL
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • UniProtKB
Synaptic vesicle endocytosisdefinition[GO:0048488] silver  
1
  • Ortholog Compara
Synaptic vesicle targetingdefinition[GO:0016080] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Asymmetric localization of PCP proteins  REACT_264478  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCRIB
GenomeRNAi: 23513
PRO: PR:Q14160