SCRIB - Protein scribble homolog - human protein (Function)
 
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SCRIB »  Protein scribble homolog  (Scribble)
 
Protein also known as:  Protein LAP4.
Gene name:  SCRIB
Entry whose protein(s) existence is based on evidence at protein level
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1 80 3
GENE REF ISO

Function

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Overview 
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.  
7
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
GO biological process 
Activation of Rac GTPase activitydefinition[GO:0032863]  
1
  • IMPUniProtKB
Apoptotic process involved in morphogenesisdefinition[GO:0060561]  
1
  • IMPUniProtKB
Astrocyte cell migrationdefinition[GO:0043615] silver  
  • IEAOrtholog Compara
Asymmetric protein localizationdefinition[GO:0008105] silver  
  • IEAOrtholog Compara
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • IDAUniProtKB
Cell-cell adhesiondefinition[GO:0016337]  
1
  • IGIUniProtKB
Establishment of apical/basal cell polaritydefinition[GO:0035089]  
1
  • IMPUniProtKB
Mammary gland duct morphogenesisdefinition[GO:0060603]  
  • ISSOrtholog Curator
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • IDAUniProtKB
Neural tube closuredefinition[GO:0001843]  
1
  • IMPUniProtKB
Positive chemotaxisdefinition[GO:0050918]  
1
  • IMPUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IMPUniProtKB
Positive regulation of receptor recyclingdefinition[GO:0001921]  
1
  • IMPUniProtKB
Protein localization to adherens junctiondefinition[GO:0071896]  
1
  • IMPBHF-UCL
Synaptic vesicle endocytosisdefinition[GO:0048488] silver  
  • IEAOrtholog Compara
Synaptic vesicle targetingdefinition[GO:0016080] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCRIB
GenomeRNAi: 23513
PRO: PR:Q14160