DCTN1 - Dynactin subunit 1 - human protein (Function)
 
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Protein
Gene
References

 
DCTN1 »  Dynactin subunit 1
 
Protein also known as:  150 kDa dynein-associated polypeptide.
Gene name:  DCTN1
Entry whose protein(s) existence is based on evidence at protein level
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1 98 6
GENE REF ISO

Function

 show evidences
Overview 
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.  
  • CuratedUniProtKB
GO molecular function 
Dynein bindingdefinition[GO:0045502] silver  
  • IEAInterPro 2 GO
Motor activitydefinition[GO:0003774]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
11
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Microtubule-based transportdefinition[GO:0010970] silver  
  • IEAInterPro 2 GO
Mitosisdefinition[GO:0007067]  
1
  • NASPINC
Nervous system developmentdefinition[GO:0007399]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Huntington's disease  hsa05016+1639  
Vasopressin-regulated water reabsorption  hsa04962+1639  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Immune System  REACT_6900  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DCTN1
GenomeRNAi: 1639
PRO: PR:Q14203