DCTN1 - Dynactin subunit 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
DCTN1 »  Dynactin subunit 1
 
Protein also known as:  150 kDa dynein-associated polypeptide.
Gene name:  DCTN1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 113 6
GENE REF ISO

Function

 show evidences
Overview 
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.  
1
  • UniProtKB
GO molecular function 
Dynein bindingdefinition[GO:0045502] silver  
1
  • InterPro 2 GO
Motor activitydefinition[GO:0003774]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
16
  • UniProtKB
  • IntAct
GO biological process 
Melanosome transportdefinition[GO:0032402] silver  
1
  • Ortholog Compara
Microtubule-based transportdefinition[GO:0010970] silver  
1
  • InterPro 2 GO
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • PINC
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB
Retrograde transport, endosome to Golgidefinition[GO:0042147]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Huntington's disease  hsa05016+1639  
Vasopressin-regulated water reabsorption  hsa04962+1639  
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  REACT_267965  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
MHC class II antigen presentation  REACT_121399  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
XBP1(S) activates chaperone genes  REACT_18273  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DCTN1
GenomeRNAi: 1639
PRO: PR:Q14203