DYNC1H1 - Cytoplasmic dynein 1 heavy chain 1 - human protein (Function)
 
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DYNC1H1 »  Cytoplasmic dynein 1 heavy chain 1
 
Protein also known as:  Cytoplasmic dynein heavy chain 1.
Gene name:  DYNC1H1
Family name: Dynein heavy chain
Entry whose protein(s) existence is based on evidence at protein level
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1 87 1
GENE REF ISO

Function

 show evidences
Overview 
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887] silver  
  • IEAInterPro 2 GO
Microtubule motor activitydefinition[GO:0003777] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cytoplasmic mRNA processing body assemblydefinition[GO:0033962]  
  • ISSOrtholog Curator
Microtubule-based movementdefinition[GO:0007018] silver  
  • IEAInterPro 2 GO
Mitotic spindle organizationdefinition[GO:0007052]  
1
  • NASUniProtKB
Stress granule assemblydefinition[GO:0034063]  
  • ISSOrtholog Curator
Transportdefinition[GO:0006810]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Phagosome  hsa04145+1778  
Salmonella infection  hsa05132+1778  
Vasopressin-regulated water reabsorption  hsa04962+1778  
According to Reactome, this protein belongs to the following pathways:
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
MHC class II antigen presentation  REACT_121399  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Motor protein  definition   [KW-0505]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DYNC1H1
GenomeRNAi: 1778
PRO: PR:Q14204