TCEB3 - Transcription elongation factor B polypeptide 3 - human protein (Function)
 
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TCEB3 »  Transcription elongation factor B polypeptide 3
 
Protein also known as:  RNA polymerase II transcription factor SIII subunit A1.
Gene name:  TCEB3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
GO biological process 
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
HIV elongation arrest and recovery  REACT_6259  
Pausing and recovery of HIV elongation  REACT_6244  
Pausing and recovery of Tat-mediated HIV elongation  REACT_6143  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Transcription Elongation  REACT_833  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Tat-mediated HIV elongation arrest and recovery  REACT_6344  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TCEB3
GenomeRNAi: 6924
PRO: PR:Q14241