TCEB3 - Transcription elongation factor B polypeptide 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
TCEB3 »  Transcription elongation factor B polypeptide 3
 
Protein also known as:  RNA polymerase II transcription factor SIII subunit A1.
Gene name:  TCEB3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 1
GENE REF ISO

Function

 show evidences
Overview 
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Contributes to ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • RefGenome
GO biological process 
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
1
  • RefGenome
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
1
  • Ortholog Compara
Transcription elongation from RNA polymerase II promoterdefinition[GO:0006368]  
1
  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathways:
Formation of HIV elongation complex in the absence of HIV Tat  R-HSA-167152  
Formation of HIV-1 elongation complex containing HIV-1 Tat  R-HSA-167200  
Formation of RNA Pol II elongation complex  R-HSA-112382  
HIV elongation arrest and recovery  R-HSA-167287  
Pausing and recovery of HIV elongation  R-HSA-167290  
Pausing and recovery of Tat-mediated HIV elongation  R-HSA-167238  
RNA Polymerase II Pre-transcription Events  R-HSA-674695  
RNA Polymerase II Transcription Elongation  R-HSA-75955  
Tat-mediated elongation of the HIV-1 transcript  R-HSA-167246  
Tat-mediated HIV elongation arrest and recovery  R-HSA-167243  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TCEB3
GenomeRNAi: 6924
PRO: PR:Q14241