CTTN - Src substrate cortactin - human protein (Function)
 
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CTTN »  Src substrate cortactin
 
Protein also known as:  Oncogene EMS1.
Gene name:  CTTN
Entry whose protein(s) existence is based on evidence at protein level
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1 311 3
GENE REF ISO

Function

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Overview 
Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • Ortholog Curator
Cell motilitydefinition[GO:0048870]  
1
  • Ortholog Curator
Focal adhesion assemblydefinition[GO:0048041]  
1
  • Ortholog Curator
Intracellular protein transportdefinition[GO:0006886]  
1
  • UniProtKB
Lamellipodium organizationdefinition[GO:0097581]  
1
  • Ortholog Curator
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237] silver  
1
  • Ortholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • Ortholog Curator
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • Ortholog Curator
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • Ortholog Curator
Regulation of axon extensiondefinition[GO:0030516]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+2017  
Pathogenic Escherichia coli infection  hsa05130+2017  
Shigellosis  hsa05131+2017  
Tight junction  hsa04530+2017  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cortactin
GenomeRNAi: 2017
PRO: PR:Q14247