CTTN - Src substrate cortactin - human protein (Function)
 
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Protein
Gene
References

 
CTTN »  Src substrate cortactin
 
Protein also known as:  Oncogene EMS1.
Gene name:  CTTN
Entry whose protein(s) existence is based on evidence at protein level
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1 308 3
GENE REF ISO

Function

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Overview 
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed23144454).  
7
  • UniProtKB
GO molecular function 
Profilin bindingdefinition[GO:0005522]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • Ortholog Curator
Actin filament polymerizationdefinition[GO:0030041] silver  
1
  • InterPro 2 GO
Cell motilitydefinition[GO:0048870]  
1
  • Ortholog Curator
Dendritic spine maintenancedefinition[GO:0097062] silver  
1
  • Ortholog Compara
Focal adhesion assemblydefinition[GO:0048041]  
1
  • Ortholog Curator
Intracellular protein transportdefinition[GO:0006886]  
1
  • UniProtKB
Lamellipodium organizationdefinition[GO:0097581]  
1
  • Ortholog Curator
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237] silver  
1
  • Ortholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • Ortholog Curator
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of smooth muscle contractiondefinition[GO:0045987]  
1
  • UniProtKB
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • Ortholog Curator
Regulation of axon extensiondefinition[GO:0030516]  
1
  • Ortholog Curator
Substrate-dependent cell migration, cell extensiondefinition[GO:0006930] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+2017  
Pathogenic Escherichia coli infection  hsa05130+2017  
Shigellosis  hsa05131+2017  
Tight junction  hsa04530+2017  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cortactin
GenomeRNAi: 2017
PRO: PR:Q14247