CTTN - Src substrate cortactin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CTTN »  Src substrate cortactin
 
Protein also known as:  Oncogene EMS1.
Gene name:  CTTN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 277 3
GENE REF ISO

Function

 show evidences
Overview 
Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
11
  • IPIUniProtKB
  • IPIIntAct
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+2017  
Pathogenic Escherichia coli infection  hsa05130+2017  
Shigellosis  hsa05131+2017  
Tight junction  hsa04530+2017  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cortactin
GenomeRNAi: 2017
PRO: PR:Q14247