FASTK - Fas-activated serine/threonine kinase - human protein (Function)
 
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FASTK »  Fas-activated serine/threonine kinase   [ EC 2.7.11.8 ]  (FAST kinase)
 
Gene name:  FASTK
Family name: FAST protein kinase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Fas-activated serine/threonine kinase activitydefinition[GO:0033867]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of RNA splicingdefinition[GO:0043484]  
2
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.8: ATP + [Fas-activated serine/threonine protein] ADP + [Fas-activated serine/threonine phosphoprotein].  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FASTK
GenomeRNAi: 10922
PRO: PR:Q14296