FLNC - Filamin-C - human protein (Function)
 
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FLNC »  Filamin-C  (FLNc)
 
Protein also known as:  Actin-binding-like protein.
Gene name:  FLNC
Family name: Filamin
Entry whose protein(s) existence is based on evidence at protein level
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1 78 2
GENE REF ISO

Function

 show evidences
Overview 
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Ankyrin bindingdefinition[GO:0030506]  
1
  • IPIBHF-UCL
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Muscle fiber developmentdefinition[GO:0048747] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Focal adhesion  hsa04510+2318  
MAPK signaling pathway  hsa04010+2318  
Salmonella infection  hsa05132+2318  
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
Note 
Silenced in MKN28 and MKN74 gastric cancer cell lines due to aberrant methylation of the gene.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FLNC_(gene)
GenomeRNAi: 2318
PRO: PR:Q14315