FKBP8 - Peptidyl-prolyl cis-trans isomerase FKBP8 - human protein (Function)
 
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FKBP8 »  Peptidyl-prolyl cis-trans isomerase FKBP8   [ EC 5.2.1.8 ]  (PPIase FKBP8)
 
Protein also known as:  38 kDa FK506-binding protein (FKBP-38).
Gene name:  FKBP8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.  
4
  • UniProtKB
GO molecular function 
FK506 bindingdefinition[GO:0005528]  
1
  • RefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • AgBase
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Camera-type eye developmentdefinition[GO:0043010] silver  
1
  • Ortholog Compara
Cell fate specificationdefinition[GO:0001708] silver  
1
  • Ortholog Compara
Chaperone-mediated protein foldingdefinition[GO:0061077]  
1
  • RefGenome
Dorsal/ventral neural tube patterningdefinition[GO:0021904] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • PINC
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
1
  • Ortholog Compara
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
1
  • RefGenome
Regulation of gene expressiondefinition[GO:0010468] silver  
1
  • Ortholog Compara
Smoothened signaling pathwaydefinition[GO:0007224] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
2
  • UniProtKB
It requires the following cofactor
 Ca(2+)  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP8
GenomeRNAi: 23770
PRO: PR:Q14318