FKBP8 - Peptidyl-prolyl cis-trans isomerase FKBP8 - human protein (Function)
 
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FKBP8 »  Peptidyl-prolyl cis-trans isomerase FKBP8   [ EC 5.2.1.8 ]  (PPIase FKBP8)
 
Protein also known as:  38 kDa FK506-binding protein (FKBP-38).
Gene name:  FKBP8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.  
3
  • CuratedUniProtKB
GO molecular function 
FK506 bindingdefinition[GO:0005528] silver  
  • IBARefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Peptidyl-proline modificationdefinition[GO:0018208] silver  
  • IBARefGenome
Protein foldingdefinition[GO:0006457]  
  • IEAUniProtKB KW
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413] silver  
  • IBARefGenome
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
1
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP8
GenomeRNAi: 23770
PRO: PR:Q14318