FZD2 - Frizzled-2 - human protein (Function)
 
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FZD2 »  Frizzled-2  (Fz-2)
 
Protein also known as:  FzE2.
Gene name:  FZD2
Entry whose protein(s) existence is based on evidence at protein level
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1 24 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Wnt-activated receptor activitydefinition[GO:0042813] silver  
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147] silver  
  • IBARefGenome
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IBARefGenome
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Cell-cell signalingdefinition[GO:0007267] silver  
  • IEAOrtholog Compara
Cochlea morphogenesisdefinition[GO:0090103] silver  
  • IEAOrtholog Compara
Embryo developmentdefinition[GO:0009790] silver  
  • IBARefGenome
Epithelial cell differentiationdefinition[GO:0030855] silver  
  • IBARefGenome
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199] silver  
  • IBARefGenome
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Hard palate developmentdefinition[GO:0060022] silver  
  • IEAOrtholog Compara
Inner ear receptor cell developmentdefinition[GO:0060119] silver  
  • IEAOrtholog Compara
Membranous septum morphogenesisdefinition[GO:0003149] silver  
  • IEAOrtholog Compara
Muscular septum morphogenesisdefinition[GO:0003150] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
  • IEAOrtholog Compara
Positive regulation of cGMP metabolic processdefinition[GO:0030825]  
1
  • IMPBHF-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDABHF-UCL
Sensory perception of smelldefinition[GO:0007608] silver  
  • IEAOrtholog Compara
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Wnt signaling pathway, calcium modulating pathwaydefinition[GO:0007223] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+2535  
HTLV-I infection  hsa05166+2535  
Melanogenesis  hsa04916+2535  
Pathways in cancer  hsa05200+2535  
Wnt signaling pathway  hsa04310+2535  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FZD2
GenomeRNAi: 2535
PRO: PR:Q14332
Chemistry
GuidetoPHARMACOLOGY: 230