GNA13 - Guanine nucleotide-binding protein subunit alpha-13 - human protein (Function)
 
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GNA13 »  Guanine nucleotide-binding protein subunit alpha-13  (G alpha-13)
 
Gene name:  GNA13
Family name: G-alpha » G(12)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  
  • CuratedUniProtKB
GO molecular function 
D5 dopamine receptor bindingdefinition[GO:0031752] silver  
  • IBARefGenome
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IBARefGenome
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Signal transducer activitydefinition[GO:0004871] silver  
  • IBARefGenome
Type 1 angiotensin receptor bindingdefinition[GO:0031702] silver  
  • IBARefGenome
GO biological process 
Activation of phospholipase D activitydefinition[GO:0031584] silver  
  • IBARefGenome
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IBARefGenome
Cell differentiationdefinition[GO:0030154] silver  
  • IEAOrtholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAInterPro 2 GO
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAOrtholog Compara
Regulation of cell shapedefinition[GO:0008360] silver  
  • IEAOrtholog Compara
Rho protein signal transductiondefinition[GO:0007266] silver  
  • IBARefGenome
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Long-term depression  hsa04730+10672  
Regulation of actin cytoskeleton  hsa04810+10672  
Vascular smooth muscle contraction  hsa04270+10672  
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNA13
GenomeRNAi: 10672
PRO: PR:Q14344