GALE - UDP-glucose 4-epimerase - human protein (Function)
 
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Protein
Gene
References

 
GALE »  UDP-glucose 4-epimerase   [ EC 5.1.3.2 ]
 
Protein also known as:  UDP-galactose 4-epimerase.
Gene name:  GALE
Family name: Sugar epimerase
Entry whose protein(s) existence is based on evidence at protein level
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1 31 1
GENE REF ISO

Function

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Overview 
Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.  
  • CuratedUniProtKB
GO molecular function 
Coenzyme bindingdefinition[GO:0050662] silver  
  • IEAInterPro 2 GO
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
UDP-glucose 4-epimerase activitydefinition[GO:0003978]  
1
  • IDAUniProtKB
GO biological process 
Cellular metabolic processdefinition[GO:0044237] silver  
  • IEAInterPro 2 GO
Galactose catabolic processdefinition[GO:0019388]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.3.2: UDP-alpha-D-glucose UDP-alpha-D-galactose.  
  • CuratedUniProtKB
It requires the following cofactor
NAD.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+2582  
Galactose metabolism  hsa00052+2582  
Metabolic pathways  hsa01100+2582  
According to Reactome, this protein belongs to the following pathway:
Galactose catabolism  REACT_532  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 69 uM for UDP-galactose (at 37 degrees Celsius and pH 8.8)
Vmax 1.22 mmol/min/mg enzyme with UDP-galactose as substrate

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Galactose metabolism  definition   [KW-0299]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q14376
Other
GenomeRNAi: 2582
PRO: PR:Q14376