GALNT3 - Polypeptide N-acetylgalactosaminyltransferase 3 - human protein (Function)
 
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GALNT3 »  Polypeptide N-acetylgalactosaminyltransferase 3   [ EC 2.4.1.41 ]
 
Protein also known as:  UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3.
Gene name:  GALNT3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 45 2
GENE REF ISO

Function

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Overview 
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.  
2
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDABHF-UCL
Manganese ion bindingdefinition[GO:0030145]  
1
  • IDABHF-UCL
Polypeptide N-acetylgalactosaminyltransferase activitydefinition[GO:0004653]  
1
  • IDABHF-UCL
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • NASPINC
Protein O-linked glycosylation via serinedefinition[GO:0018242]  
1
  • IDABHF-UCL
Protein O-linked glycosylation via threoninedefinition[GO:0018243]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.41: UDP-N-acetyl-alpha-D-galactosamine + polypeptide UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.  
1
  • CuratedUniProtKB
It requires the following cofactor
Manganese (By similarity).  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathways:
Carbohydrate-Binding Module Family 13  CBM13  
Glycosyltransferase Family 27  GT27  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+2591  
Mucin type O-Glycan biosynthesis  hsa00512+2591  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
Note 
Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GALNT3
GenomeRNAi: 2591
PRO: PR:Q14435