GRB14 - Growth factor receptor-bound protein 14 - human protein (Function)
 
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Protein
Gene
References

 
GRB14 »  Growth factor receptor-bound protein 14
 
Protein also known as:  GRB14 adapter protein.
Gene name:  GRB14
Family name: GRB7/10/14
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

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Overview 
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.  
2
  • CuratedUniProtKB
GO molecular function 
SH3/SH2 adaptor activitydefinition[GO:0005070] silver  
  • IEAOrtholog Compara
GO biological process 
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GRB14
GenomeRNAi: 2888
PRO: PR:Q14449