GRB7 - Growth factor receptor-bound protein 7 - human protein (Function)
 
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GRB7 »  Growth factor receptor-bound protein 7
 
Protein also known as:  Epidermal growth factor receptor GRB-7.
Gene name:  GRB7
Family name: GRB7/10/14
Entry whose protein(s) existence is based on evidence at protein level
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1 75 4
GENE REF ISO

Function

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Overview 
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).  
4
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Phosphatidylinositol bindingdefinition[GO:0035091]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IDAUniProtKB
RNA bindingdefinition[GO:0003723]  
  • IEAUniProtKB KW
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASPINC
GO biological process 
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • TASPINC
Negative regulation of translationdefinition[GO:0017148]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
2
  • IDAUniProtKB
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Stress granule assemblydefinition[GO:0034063]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Downstream signal transduction  REACT_17025  
GRB7 events in ERBB2 signaling  REACT_115896  
Signaling by SCF-KIT  REACT_111040  
Tie2 Signaling  REACT_12621  
 

Keywords

Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GRB7
GenomeRNAi: 2886
PRO: PR:Q14451