KCNJ12 - ATP-sensitive inward rectifier potassium channel 12 - human protein (Function)
 
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Protein
Gene
References

 
KCNJ12 »  ATP-sensitive inward rectifier potassium channel 12
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 12.
Gene name:  KCNJ12
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.  
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  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.9  
GO molecular function 
Inward rectifier potassium channel activitydefinition[GO:0005242]  
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  • IDAUniProtKB
GO biological process 
Muscle contractiondefinition[GO:0006936]  
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  • TASPINC
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDAGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • IDAUniProtKB
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IDAUniProtKB
Regulation of heart contractiondefinition[GO:0008016]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+3768  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ12
GenomeRNAi: 3768
PRO: PR:Q14500
Chemistry
GuidetoPHARMACOLOGY: 431