HABP2 - Hyaluronan-binding protein 2 - human protein (Function)
 
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Protein
Gene
References

 
HABP2 »  Hyaluronan-binding protein 2   [ EC 3.4.21.- ]
 
Protein also known as:  Hepatocyte growth factor activator-like protein. Cleaved into:  Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form; Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form.
Gene name:  HABP2
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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1 56 2
GENE REF ISO

Function

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Overview 
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.  
3
  • CuratedUniProtKB
GO molecular function 
Glycosaminoglycan bindingdefinition[GO:0005539]  
1
  • TASPINC
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q14520
Other
GeneWiki: HABP2
GenomeRNAi: 3026
PRO: PR:Q14520