SCN5A - Sodium channel protein type 5 subunit alpha - human protein (Function)
 
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SCN5A »  Sodium channel protein type 5 subunit alpha
 
Protein also known as:  Sodium channel protein cardiac muscle subunit alpha.
Gene name:  SCN5A
Entry whose protein(s) existence is based on evidence at protein level
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1 355 6
GENE REF ISO

Function

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Overview 
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.10.3  
GO molecular function 
Ankyrin bindingdefinition[GO:0030506]  
1
  • IDABHF-UCL
Calmodulin bindingdefinition[GO:0005516]  
1
  • IPIBHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Fibroblast growth factor bindingdefinition[GO:0017134]  
1
  • IPIBHF-UCL
Ion channel bindingdefinition[GO:0044325]  
2
  • IPIBHF-UCL
Nitric-oxide synthase bindingdefinition[GO:0050998]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIBHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • IPIBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIBHF-UCL
Voltage-gated sodium channel activitydefinition[GO:0005248]  
5
  • IDABHF-UCL
  • IDAUniProtKB
Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialdefinition[GO:0086006]  
4
  • IMPBHF-UCL
GO biological process 
AV node cell to bundle of His cell communicationdefinition[GO:0086067]  
2
  • IMPBHF-UCL
Brainstem developmentdefinition[GO:0003360]  
  • ISSOrtholog Curator
Bundle of His cell to Purkinje myocyte communicationdefinition[GO:0086069]  
1
  • IMPBHF-UCL
Cardiac muscle cell action potential involved in contractiondefinition[GO:0086002]  
1
  • IMPBHF-UCL
Cardiac muscle contractiondefinition[GO:0060048]  
3
  • IMPBHF-UCL
Cardiac ventricle developmentdefinition[GO:0003231]  
  • ISSOrtholog Curator
Cellular response to calcium iondefinition[GO:0071277]  
1
  • IDAUniProtKB
Cerebellum developmentdefinition[GO:0021549]  
  • ISSOrtholog Curator
Membrane depolarizationdefinition[GO:0051899]  
3
  • IDABHF-UCL
Membrane depolarization during action potentialdefinition[GO:0086010]  
3
  • IDABHF-UCL
Membrane depolarization during cardiac muscle cell action potentialdefinition[GO:0086012]  
1
  • IMPBHF-UCL
Membrane depolarization during SA node cell action potentialdefinition[GO:0086046]  
  • ISSOrtholog Curator
Neuronal action potentialdefinition[GO:0019228] silver  
  • IBARefGenome
Odontogenesis of dentin-containing toothdefinition[GO:0042475]  
  • ISSOrtholog Curator
Positive regulation of action potentialdefinition[GO:0045760]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
  • ISSOrtholog Curator
Positive regulation of sodium ion transportdefinition[GO:0010765]  
4
  • IDABHF-UCL
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371]  
2
  • IMPBHF-UCL
Regulation of atrial cardiac muscle cell membrane repolarizationdefinition[GO:0060372]  
1
  • IMPBHF-UCL
Regulation of cardiac muscle cell contractiondefinition[GO:0086004]  
1
  • IMPBHF-UCL
Regulation of heart ratedefinition[GO:0002027]  
5
  • IMPBHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of sodium ion transmembrane transportdefinition[GO:1902305]  
1
  • IDABHF-UCL
Regulation of ventricular cardiac muscle cell membrane depolarizationdefinition[GO:0060373]  
3
  • IMPBHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • IMPBHF-UCL
Response to denervation involved in regulation of muscle adaptationdefinition[GO:0014894]  
  • ISSOrtholog Curator
SA node cell to atrial cardiac muscle cell communicationdefinition[GO:0086070]  
1
  • IMPBHF-UCL
Sodium ion transmembrane transportdefinition[GO:0035725]  
3
  • IMPBHF-UCL
Sodium ion transportdefinition[GO:0006814]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Telencephalon developmentdefinition[GO:0021537]  
  • ISSOrtholog Curator
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
2
  • IMPBHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
Note 
Na(+) channels in mammalian cardiac membrane have functional properties quite distinct from Na(+) channels in nerve and skeletal muscle.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Nav1.5
GenomeRNAi: 6331
PRO: PR:Q14524
Chemistry
GuidetoPHARMACOLOGY: 582