INPP5A - Type I inositol 1,4,5-trisphosphate 5-phosphatase - human protein (Function)
 
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INPP5A »  Type I inositol 1,4,5-trisphosphate 5-phosphatase   [ EC 3.1.3.56 ]  (5PTase)
 
Gene name:  INPP5A
Entry whose protein(s) existence is based on evidence at protein level
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1 19 1
GENE REF ISO

Function

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Overview 
Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.  
  • CuratedUniProtKB
GO molecular function 
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activitydefinition[GO:0052659]  
  • IEAEC 2 GO
Inositol-1,4,5-trisphosphate 5-phosphatase activitydefinition[GO:0052658]  
  • IEAEC 2 GO
Inositol-polyphosphate 5-phosphatase activitydefinition[GO:0004445]  
1
  • NASUniProtKB
PH domain bindingdefinition[GO:0042731]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Phosphatidylinositol dephosphorylationdefinition[GO:0046856] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
D-myo-inositol 1,4,5-trisphosphate + H(2)O myo-inositol 1,4-bisphosphate + phosphate.  
  • CuratedUniProtKB
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O 1D-myo-inositol 1,3,4-trisphosphate + phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Inositol phosphate metabolism  hsa00562+3632  
Metabolic pathways  hsa01100+3632  
Phosphatidylinositol signaling system  hsa04070+3632  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: INPP5A
GenomeRNAi: 3632
PRO: PR:Q14642