ITPR1 - Inositol 1,4,5-trisphosphate receptor type 1 - human protein (Function)
 
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ITPR1 »  Inositol 1,4,5-trisphosphate receptor type 1
 
Protein also known as:  Type 1 inositol 1,4,5-trisphosphate receptor (Type 1 InsP3 receptor).
Gene name:  ITPR1
Family name: InsP3 receptor
Entry whose protein(s) existence is based on evidence at protein level
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1 102 8
GENE REF ISO

Function

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Overview 
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family  1.A.3.2.6  
GO molecular function 
Calcium ion transmembrane transporter activitydefinition[GO:0015085]  
1
  • TASPINC
Inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitydefinition[GO:0005220]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Intracellular ligand-gated calcium channel activitydefinition[GO:0005218]  
  • ISSOrtholog Curator
Phosphatidylinositol bindingdefinition[GO:0035091]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Calcium ion transportdefinition[GO:0006816]  
1
  • NASUniProtKB
Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469] silver  
  • IEAOrtholog Compara
Inositol phosphate-mediated signalingdefinition[GO:0048016]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • ISSOrtholog Curator
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
  • ISSOrtholog Curator
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
  • ISSOrtholog Curator
Response to hypoxiadefinition[GO:0001666]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • NASUniProtKB
Voluntary musculoskeletal movementdefinition[GO:0050882] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+3708  
Calcium signaling pathway  hsa04020+3708  
Cholinergic synapse  hsa04725+3708  
Dopaminergic synapse  hsa04728+3708  
Gap junction  hsa04540+3708  
Gastric acid secretion  hsa04971+3708  
Glutamatergic synapse  hsa04724+3708  
GnRH signaling pathway  hsa04912+3708  
Huntington's disease  hsa05016+3708  
Long-term depression  hsa04730+3708  
Long-term potentiation  hsa04720+3708  
Oocyte meiosis  hsa04114+3708  
Pancreatic secretion  hsa04972+3708  
Phosphatidylinositol signaling system  hsa04070+3708  
Salivary secretion  hsa04970+3708  
Vascular smooth muscle contraction  hsa04270+3708  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
Ca2+ pathway  REACT_172761  
cGMP effects  REACT_23767  
DAG and IP3 signaling  REACT_111064  
Effects of PIP2 hydrolysis  REACT_2202  
Elevation of cytosolic Ca2+ levels  REACT_162  
FCERI mediated Ca+2 mobilization  REACT_163834  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
PLC beta mediated events  REACT_15426  
Regulation of insulin secretion  REACT_18325  
Role of phospholipids in phagocytosis  REACT_160158  
Caution 
Alternative splice sites (AA 1053-1054) represent a non-canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ITPR1
GenomeRNAi: 3708
PRO: PR:Q14643
Chemistry
GuidetoPHARMACOLOGY: 743