KCNJ11 - ATP-sensitive inward rectifier potassium channel 11 - human protein (Function)
 
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Protein
Gene
References

 
KCNJ11 »  ATP-sensitive inward rectifier potassium channel 11
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 11.
Gene name:  KCNJ11
Entry whose protein(s) existence is based on evidence at protein level
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1 190 2
GENE REF ISO

Function

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Overview 
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.  
2
  • CuratedUniProtKB
GO molecular function 
Ankyrin bindingdefinition[GO:0030506]  
1
  • IPIBHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • ISSBHF-UCL
ATP-activated inward rectifier potassium channel activitydefinition[GO:0015272]  
  • ISSOrtholog Curator
Heat shock protein bindingdefinition[GO:0031072] silver  
  • IEAOrtholog Compara
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Potassium ion bindingdefinition[GO:0030955]  
1
  • TASBHF-UCL
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • IDABHF-UCL
GO biological process 
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to nicotinedefinition[GO:0071316] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Glucose metabolic processdefinition[GO:0006006]  
2
  • IMPBHF-UCL
Negative regulation of insulin secretiondefinition[GO:0046676]  
1
  • IMPBHF-UCL
Neurological system processdefinition[GO:0050877]  
2
  • IMPBHF-UCL
Positive regulation of cation channel activitydefinition[GO:2001259] silver  
  • IEAOrtholog Compara
Potassium ion importdefinition[GO:0010107]  
  • ISSOrtholog Curator
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDABHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • IMPBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Response to ATPdefinition[GO:0033198]  
2
  • IDABHF-UCL
Response to drugdefinition[GO:0042493]  
1
  • IMPBHF-UCL
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to ischemiadefinition[GO:0002931] silver  
  • IEAOrtholog Compara
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Kir6.2
GenomeRNAi: 3767
PRO: PR:Q14654
Chemistry
GuidetoPHARMACOLOGY: 442