KCNJ11 - ATP-sensitive inward rectifier potassium channel 11 - human protein (Sequence)
 
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KCNJ11 »  ATP-sensitive inward rectifier potassium channel 11
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 11.
Gene name:  KCNJ11
Entry whose protein(s) existence is based on evidence at protein level
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1 190 2
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   390 aaMass: 43541 Da,  pI: 8.15
MLSRKGIIPE EYVLTRLAED PAEPRYRARQ RRARFVSKKG NCNVAHKNIR EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTIKVP TPLCTARQLD EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS

Sequence

 show evidences
PTM 
Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.  
  • CuratedUniProtKB
Sequence caution 
The sequence AAH40617 differs from that shown. Reason: erroneous initiation.Translation N-terminally shortened.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Phosphoprotein  definition   [KW-0597]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.60.40.1400
InterPro: IPR013518 [ K chnl inward-rec Kir cyto ]
InterPro: IPR003279 [ K chnl inward-rec Kir6.2 ]
InterPro: IPR016449 [ K chnl inward-rec Kir ]
InterPro: IPR014756 [ Ig E-set ]
PANTHER: PTHR11767 [ PTHR11767 ]
Pfam: PF01007 [ IRK ]
PIRSF: PIRSF005465 [ GIRK kir ]
PRINTS: PR01320 [ KIRCHANNEL ]
PRINTS: PR01332 [ KIR62CHANNEL ]
SUPFAM: SSF81296 [ SSF81296 ]
Genome annotation databases
Ensembl: Transcript: ENST00000339994;  Protein: ENSP00000345708;  Gene: ENSG00000187486.
Ensembl: Transcript: ENST00000528731;  Protein: ENSP00000434755;  Gene: ENSG00000187486.
Ensembl: Transcript: ENST00000526912;  Protein: ENSP00000432729;  Gene: ENSG00000187486.
Ensembl: Transcript: ENST00000528992;  Protein: ENSP00000436479;  Gene: ENSG00000187486.
KEGG: hsa:3767
UCSC: uc001mnb.4
Organism-specific databases
MGI: MGI:107501 [ Kcnj11 ]
Other
ChiTaRS: KCNJ11
PTM databases
PhosphoSite: Q14654
Phylogenomic databases
eggNOG: NOG72812
HOGENOM: HOG000237325
HOVERGEN: HBG006178
InParanoid: Q14654
KO: K05004
OrthoDB: EOG7XPZ5K
Sequence databases
CCDS: CCDS53606.1 [ Q14654-2 ]
CCDS: CCDS31436.1 [ Q14654-1 ]
EMBL: mRNA:  BC112358 . Translation:  AAI12359.1 .
EMBL: mRNA:  BC064497 . Translation:  AAH64497.1 .
EMBL: Genomic DNA:  AC124798 . No translation available.
EMBL: Genomic DNA:  D50582 . Translation:  BAA09131.1 .
EMBL: mRNA:  AK301550 . Translation:  BAG63046.1 .
EMBL: mRNA:  BC040617 . Translation:  AAH40617.1 . Different initiation.
IPI: IPI00953564
IPI: IPI00291902
PIR: A57616
RefSeq: Protein:  NP_001159762.1. Nucleotide sequence:  NM_001166290.1.
UniProtKB: Q14654 [ KCNJ11 ]