KANK1 - KN motif and ankyrin repeat domain-containing protein 1 - human protein (Function)
 
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KANK1 »  KN motif and ankyrin repeat domain-containing protein 1
 
Protein also known as:  Ankyrin repeat domain-containing protein 15.
Gene name:  KANK1
Entry whose protein(s) existence is based on evidence at protein level
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1 43 2
GENE REF ISO

Function

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Overview 
Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.  
5
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
GO biological process 
Negative regulation of actin filament polymerizationdefinition[GO:0030837]  
2
  • IDAUniProtKB
  • IDAMGI
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPUniProtKB
Negative regulation of insulin receptor signaling pathwaydefinition[GO:0046627]  
1
  • IMPUniProtKB
Negative regulation of lamellipodium morphogenesisdefinition[GO:2000393]  
1
  • IDAUniProtKB
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
1
  • IDAUniProtKB
Negative regulation of Rho protein signal transductiondefinition[GO:0035024]  
1
  • IMPUniProtKB
Negative regulation of ruffle assemblydefinition[GO:1900028]  
1
  • IDAUniProtKB
Negative regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900025]  
1
  • IDAUniProtKB
Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
1
  • IMPUniProtKB
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IDAUniProtKB
Positive regulation of wound healingdefinition[GO:0090303]  
1
  • IMPUniProtKB
Regulation of establishment of cell polaritydefinition[GO:2000114]  
1
  • IMPUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ANKRD15
GenomeRNAi: 23189
PRO: PR:Q14678