KCNB1 - Potassium voltage-gated channel subfamily B member 1 - human protein (Function)
 
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KCNB1 »  Potassium voltage-gated channel subfamily B member 1
 
Protein also known as:  Voltage-gated potassium channel subunit Kv2.1.
Gene name:  KCNB1
Entry whose protein(s) existence is based on evidence at protein level
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1 69 1
GENE REF ISO

Function

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Overview 
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed8081723, PubMed1283219, PubMed10484328, PubMed12560340, PubMed19074135, PubMed19717558, PubMed24901643). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed10484328, PubMed11852086, PubMed12060745, PubMed19074135, PubMed19717558, PubMed24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity).  
13
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.2.11  
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
4
  • UniProtKB
  • RefGenome
  • Ortholog Curator
Ion channel bindingdefinition[GO:0044325]  
1
  • UniProtKB
Outward rectifier potassium channel activitydefinition[GO:0015271] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • Ortholog Curator
Protein N-terminus bindingdefinition[GO:0047485] silver  
1
  • Ortholog Compara
Ubiquitin-like protein bindingdefinition[GO:0032182]  
1
  • UniProtKB
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • UniProtKB
Cellular response to glucose stimulusdefinition[GO:0071333]  
1
  • Ortholog Curator
Cellular response to nutrient levelsdefinition[GO:0031669]  
1
  • Ortholog Curator
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Glutamate receptor signaling pathwaydefinition[GO:0007215]  
1
  • Ortholog Curator
Negative regulation of insulin secretiondefinition[GO:0046676]  
1
  • Ortholog Curator
Positive regulation of calcium ion-dependent exocytosisdefinition[GO:0045956]  
1
  • Ortholog Curator
Positive regulation of catecholamine secretiondefinition[GO:0033605]  
1
  • Ortholog Curator
Positive regulation of long term synaptic depressiondefinition[GO:1900454]  
1
  • Ortholog Curator
Positive regulation of norepinephrine secretiondefinition[GO:0010701]  
1
  • Ortholog Curator
Positive regulation of protein targeting to membranedefinition[GO:0090314]  
2
  • UniProtKB
  • Ortholog Curator
Potassium ion transmembrane transportdefinition[GO:0071805]  
4
  • UniProtKB
  • Ortholog Curator
  • RefGenome
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Protein targeting to plasma membranedefinition[GO:0072661]  
1
  • Ortholog Curator
Regulation of action potentialdefinition[GO:0098900]  
1
  • Ortholog Curator
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Regulation of motor neuron apoptotic processdefinition[GO:2000671]  
1
  • Ortholog Curator
Vesicle docking involved in exocytosisdefinition[GO:0006904]  
1
  • Ortholog Curator
Enzymatic activity 
It is regulated in the following manner
Inhibited by 12.7 nM stromatoxin 1 (ScTx1), a spider venom toxin of the tarantula S.calceata (PubMed14565763). Inhibited by 42 nM hanatoxin 1 (HaTx1), a spider venom toxin of the tarantula G.spatulata (PubMed14565763). Modestly sensitive to millimolar levels of tetraethylammonium (TEA) (PubMed8081723, PubMed1283219). Modestly sensitive to millimolar levels of 4-aminopyridine (4-AP). Completely insensitive to toxins such as dendrotoxin (DTX) and charybdotoxin (CTX) (By similarity).  
7
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+3745  
According to Reactome, this protein belongs to the following pathways:
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Voltage gated Potassium channels  R-HSA-1296072  
 

Keywords

Biological process 
Exocytosis  definition   [KW-0268]
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNB1
GenomeRNAi: 3745
PRO: PR:Q14721
Chemistry
GuidetoPHARMACOLOGY: 546