KCNAB1 - Voltage-gated potassium channel subunit beta-1 - human protein (Function)
 
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Protein
Gene
References

 
KCNAB1 »  Voltage-gated potassium channel subunit beta-1   [ EC 1.1.1.- ]
 
Protein also known as:  K(+) channel subunit beta-1.
Gene name:  KCNAB1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed7499366, PubMed7603988, PubMed17156368,PubMed17540341, PubMed19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed7499366, PubMed7890032, PubMed7603988, PubMed7649300, PubMed8938711, PubMed12077175, PubMed12130714, PubMed15361858, PubMed17540341, PubMed19713757). Accelerates KCNA4 channel closure (PubMed7890032, PubMed7649300, PubMed7890764, PubMed9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity).  
15
  • UniProtKB
Isoform  KvB1.2   Has no effect on KCNA1, KCNA2 or KCNB1 (PubMed7890032, PubMed7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).  
16
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated k(+) channel -subunit (kv) family  8.A.5.1.1  
GO molecular function 
Aldo-keto reductase (NADP) activitydefinition[GO:0004033]  
1
  • Ortholog Curator
NADPH bindingdefinition[GO:0070402]  
1
  • UniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
2
  • UniProtKB
Voltage-gated potassium channel activitydefinition[GO:0005249] silver  
1
  • InterPro 2 GO
GO biological process 
Learning or memorydefinition[GO:0007611] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • Ortholog Curator
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • InterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of delayed rectifier potassium channel activitydefinition[GO:1902259]  
1
  • Ortholog Curator
Regulation of potassium ion transmembrane transportdefinition[GO:1901379]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Oxidoreductase  definition   [KW-0560]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNAB1
GenomeRNAi: 7881
PRO: PR:Q14722