LTBP1 - Latent-transforming growth factor beta-binding protein 1 - human protein (Function)
 
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Protein
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References

 
LTBP1 »  Latent-transforming growth factor beta-binding protein 1  (LTBP-1)
 
Protein also known as:  Transforming growth factor beta-1-binding protein 1 (TGF-beta1-BP-1).
Gene name:  LTBP1
Family name: LTBP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 5
GENE REF ISO

Function

 show evidences
Overview 
May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Transforming growth factor beta bindingdefinition[GO:0050431]  
2
  • IPIUniProtKB
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024]  
1
  • NASUniProtKB
GO biological process 
Sequestering of TGFbeta in extracellular matrixdefinition[GO:0035583]  
1
  • TASBHF-UCL
Transmembrane receptor protein serine/threonine kinase signaling pathwaydefinition[GO:0007178]  
1
  • NASGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+4052  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LTBP1_(gene)
GenomeRNAi: 4052
PRO: PR:Q14766