GRM7 - Metabotropic glutamate receptor 7 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GRM7 »  Metabotropic glutamate receptor 7  (mGluR7)
 
Gene name:  GRM7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 5
GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.  
1
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase inhibitor activitydefinition[GO:0010855]  
2
  • IDAUniProtKB
Calcium channel regulator activitydefinition[GO:0005246] silver  
  • IBARefGenome
Isoform  Iso 1   Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Isoform  Iso 2   Glutamate bindingdefinition[GO:0016595]  
1
  • IDAUniProtKB
Glutamate receptor activitydefinition[GO:0008066]  
1
  • IDAUniProtKB
Group III metabotropic glutamate receptor activitydefinition[GO:0001642]  
2
  • IDAUniProtKB
Isoform  Iso 1   PDZ domain bindingdefinition[GO:0030165]  
1
  • NASUniProtKB
Serine bindingdefinition[GO:0070905]  
1
  • IDAUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IEAOrtholog Compara
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathwaydefinition[GO:0007196]  
1
  • IDAUniProtKB
Adult behaviordefinition[GO:0030534] silver  
  • IEAOrtholog Compara
Not  Behavioral fear responsedefinition[GO:0001662]  
1
  • IMPUniProtKB
Conditioned taste aversiondefinition[GO:0001661] silver  
  • IEAOrtholog Compara
Isoform  Iso 2   Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • IDAUniProtKB
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818]  
2
  • IDAUniProtKB
Negative regulation of glutamate secretiondefinition[GO:0014050]  
  • ISSOrtholog Curator
Regulation of cyclase activitydefinition[GO:0031279]  
1
  • IDAGOC
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966] silver  
  • IBARefGenome
Sensory perception of smelldefinition[GO:0007608]  
  • IEAUniProtKB KW
Sensory perception of sounddefinition[GO:0007605]  
1
  • IMPUniProtKB
Short-term memorydefinition[GO:0007614] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • IDAUniProtKB
Transmission of nerve impulsedefinition[GO:0019226] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glutamatergic synapse  hsa04724+2917  
Neuroactive ligand-receptor interaction  hsa04080+2917  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Olfaction  definition   [KW-0552]
Sensory transduction  definition   [KW-0716]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Metabotropic_glutamate_receptor_7
GenomeRNAi: 2917
PRO: PR:Q14831
Chemistry
GuidetoPHARMACOLOGY: 295