GRM3 - Metabotropic glutamate receptor 3 - human protein (Function)
 
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GRM3 »  Metabotropic glutamate receptor 3  (mGluR3)
 
Gene name:  GRM3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 65 2
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium channel regulator activitydefinition[GO:0005246] silver  
  • IEAOrtholog Compara
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASUniProtKB
Glutamate receptor activitydefinition[GO:0008066]  
1
  • TASUniProtKB
Group II metabotropic glutamate receptor activitydefinition[GO:0001641] silver  
  • IBARefGenome
Not  Group III metabotropic glutamate receptor activitydefinition[GO:0001642] silver  
  • IBARefGenome
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathwaydefinition[GO:0007196] silver  
  • IBARefGenome
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • TASPINC
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966] silver  
  • IBARefGenome
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glutamatergic synapse  hsa04724+2913  
Neuroactive ligand-receptor interaction  hsa04080+2913  
According to Reactome, this protein belongs to the following pathways:
Class C/3 (Metabotropic glutamate/pheromone receptors)  REACT_18319  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Metabotropic_glutamate_receptor_3
GenomeRNAi: 2913
PRO: PR:Q14832
Chemistry
GuidetoPHARMACOLOGY: 291