MYBPC3 - Myosin-binding protein C, cardiac-type - human protein (Function)
 
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MYBPC3 »  Myosin-binding protein C, cardiac-type  (Cardiac MyBP-C)
 
Protein also known as:  C-protein, cardiac muscle isoform.
Gene name:  MYBPC3
Family name: Immunoglobulin » MyBP
Entry whose protein(s) existence is based on evidence at protein level
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1 121 2
GENE REF ISO

Function

 show evidences
Overview 
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
ATPase activator activitydefinition[GO:0001671]  
  • ISSOrtholog Curator
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Myosin bindingdefinition[GO:0017022]  
1
  • IDABHF-UCL
Myosin heavy chain bindingdefinition[GO:0032036]  
1
  • IPIBHF-UCL
Structural constituent of muscledefinition[GO:0008307]  
1
  • IMPBHF-UCL
Titin bindingdefinition[GO:0031432]  
1
  • NASBHF-UCL
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Heart morphogenesisdefinition[GO:0003007]  
1
  • IMPBHF-UCL
Myosin filament assemblydefinition[GO:0031034] silver  
  • IEAOrtholog Compara
Positive regulation of ATPase activitydefinition[GO:0032781]  
  • ISSOrtholog Curator
Regulation of heart ratedefinition[GO:0002027] silver  
  • IEAOrtholog Compara
Regulation of muscle filament slidingdefinition[GO:0032971]  
  • ISSOrtholog Curator
Regulation of striated muscle contractiondefinition[GO:0006942]  
  • ISSOrtholog Curator
Sarcomere organizationdefinition[GO:0045214] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
2
  • IMPBHF-UCL
  • IMPHGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dilated cardiomyopathy  hsa05414+4607  
Hypertrophic cardiomyopathy (HCM)  hsa05410+4607  
According to Reactome, this protein belongs to the following pathway:
Striated Muscle Contraction  REACT_16969  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links