NFATC4 - Nuclear factor of activated T-cells, cytoplasmic 4 - human protein (Function)
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NFATC4 »  Nuclear factor of activated T-cells, cytoplasmic 4  (NFATc4)
Protein also known as:  T-cell transcription factor NFAT3 (NF-AT3).
Gene name:  NFATC4
Entry whose protein(s) existence is based on evidence at protein level
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Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Peroxisome proliferator activated receptor bindingdefinition[GO:0042975] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
  • IEAOrtholog Compara
Transcription coactivator activitydefinition[GO:0003713]  
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular respirationdefinition[GO:0045333] silver  
  • IEAOrtholog Compara
Cellular response to lithium iondefinition[GO:0071285] silver  
  • IEAOrtholog Compara
Cellular response to UVdefinition[GO:0034644] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IEAOrtholog Compara
Muscle cell developmentdefinition[GO:0055001] silver  
  • IEAOrtholog Compara
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Smooth muscle cell differentiationdefinition[GO:0051145] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+4776  
B cell receptor signaling pathway  hsa04662+4776  
HTLV-I infection  hsa05166+4776  
MAPK signaling pathway  hsa04010+4776  
Natural killer cell mediated cytotoxicity  hsa04650+4776  
T cell receptor signaling pathway  hsa04660+4776  
VEGF signaling pathway  hsa04370+4776  
Wnt signaling pathway  hsa04310+4776  


Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: NFATC4
GenomeRNAi: 4776
PRO: PR:Q14934