NFIX - Nuclear factor 1 X-type - human protein (Function)
 
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NFIX »  Nuclear factor 1 X-type  (NF1-X)
 
Protein also known as:  CCAAT-box-binding transcription factor (CTF).
Gene name:  NFIX
Family name: CTF/NF-I
Entry whose protein(s) existence is based on evidence at protein level
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1 28 5
GENE REF ISO

Function

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Overview 
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • TASPINC
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
GO biological process 
Astrocyte differentiationdefinition[GO:0048708] silver  
  • IEAOrtholog Compara
Cerebellar granule cell differentiationdefinition[GO:0021707] silver  
  • IEAOrtholog Compara
Cerebellar Purkinje cell layer developmentdefinition[GO:0021680] silver  
  • IEAOrtholog Compara
DNA replicationdefinition[GO:0006260]  
  • IEAUniProtKB KW
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
DNA replication  definition   [KW-0235]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NFIX
GenomeRNAi: 4784
PRO: PR:Q14938