SLC9A5 - Sodium/hydrogen exchanger 5 - human protein (Function)
 
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Protein
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References

 
SLC9A5 »  Sodium/hydrogen exchanger 5
 
Protein also known as:  Solute carrier family 9 member 5.
Gene name:  SLC9A5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the monovalent cation:proton antiporter-1 (cpa1) family  2.A.36.1.16  
GO molecular function 
Sodium:proton antiporter activitydefinition[GO:0015385] silver  
  • IEAInterPro 2 GO
GO biological process 
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
  • IEAInterPro 2 GO
Regulation of pHdefinition[GO:0006885] silver  
  • IEAInterPro 2 GO
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
  • IEAInterPro 2 GO
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Sodium/Proton exchangers  REACT_19314  
Caution 
The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC9A5
GenomeRNAi: 6553
PRO: PR:Q14940