NUMA1 - Nuclear mitotic apparatus protein 1 - human protein (Function)
 
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Protein
Gene
References

 
NUMA1 »  Nuclear mitotic apparatus protein 1  (NuMA protein)
 
Protein also known as:  Nuclear matrix protein-22 (NMP-22).
Gene name:  NUMA1
Entry whose protein(s) existence is based on evidence at protein level
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1 157 5
GENE REF ISO

Function

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Overview 
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.  
2
  • UniProtKB
GO molecular function 
Microtubule bindingdefinition[GO:0008017] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Structural molecule activitydefinition[GO:0005198]  
1
  • PINC
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Establishment of mitotic spindle orientationdefinition[GO:0000132] silver  
1
  • Ortholog Compara
Lung epithelial cell differentiationdefinition[GO:0060487] silver  
1
  • Ortholog Compara
Meiotic cell cycledefinition[GO:0051321] silver  
1
  • Ortholog Compara
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB KW
Nucleus organizationdefinition[GO:0006997]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Recruitment of NuMA to mitotic centrosomes  REACT_15510  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links