NR1I3 - Nuclear receptor subfamily 1 group I member 3 - human protein (Function)
 
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NR1I3 »  Nuclear receptor subfamily 1 group I member 3
 
Protein also known as:  Constitutive activator of retinoid response (Constitutive active response).
Gene name:  NR1I3
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.  
  • CuratedUniProtKB
GO molecular function 
Androgen receptor activitydefinition[GO:0004882]  
1
  • TASPINC
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • TASPINC
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Thyroid hormone receptor activitydefinition[GO:0004887] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • TASGOC
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
2
  • TASGOC
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
2
  • TASGOC
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Constitutive_androstane_receptor
GenomeRNAi: 9970
PRO: PR:Q14994
Chemistry
GuidetoPHARMACOLOGY: 607