SART3 - Squamous cell carcinoma antigen recognized by T-cells 3 - human protein (Function)
 
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SART3 »  Squamous cell carcinoma antigen recognized by T-cells 3  (SART-3)
 
Protein also known as:  Tat-interacting protein of 110 kDa (Tip110).
Gene name:  SART3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).  
6
  • UniProtKB
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.  
2
  • UniProtKB
GO molecular function 
Histone bindingdefinition[GO:0042393]  
1
  • UniProtKB
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
Contradiction  U4 snRNA bindingdefinition[GO:0030621]  
3
  • UniProtKB
Isoforms  Iso 1 , Iso 3 and Iso 4 but not isoform  Iso 2   U6 snRNA bindingdefinition[GO:0017070]  
3
  • UniProtKB
U6atac snRNA bindingdefinition[GO:0030624]  
1
  • UniProtKB
Ubiquitin-specific protease bindingdefinition[GO:1990381]  
2
  • UniProtKB
GO biological process 
Cell morphogenesisdefinition[GO:0000902] silver  
1
  • Ortholog Compara
Hematopoietic stem cell proliferationdefinition[GO:0071425] silver  
1
  • Ortholog Compara
Homeostasis of number of cellsdefinition[GO:0048872] silver  
1
  • Ortholog Compara
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • UniProtKB
Nucleosome assemblydefinition[GO:0006334]  
1
  • UniProtKB
Positive regulation of histone deubiquitinationdefinition[GO:1903586]  
1
  • UniProtKB
Regulation of gene expressiondefinition[GO:0010468]  
1
  • MGI
Isoforms  Iso 1 , Iso 3 and Iso 4 but not isoform  Iso 2   Spliceosomal snRNP assemblydefinition[GO:0000387]  
2
  • UniProtKB
Spliceosomal tri-snRNP complex assemblydefinition[GO:0000244]  
2
  • UniProtKB
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SART3
GenomeRNAi: 9733
PRO: PR:Q15020