EXOSC7 - Exosome complex component RRP42 - human protein (Function)
 
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EXOSC7 »  Exosome complex component RRP42
 
Protein also known as:  Ribosomal RNA-processing protein 42.
Gene name:  EXOSC7
Family name: RNase PH
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  
  • CuratedUniProtKB
GO molecular function 
3'-5'-exoribonuclease activitydefinition[GO:0000175]  
1
  • TASUniProtKB
Not  Exoribonuclease activitydefinition[GO:0004532]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIIntAct
RNA bindingdefinition[GO:0003723]  
1
  • TASUniProtKB
GO biological process 
RNA catabolic processdefinition[GO:0006401]  
1
  • NASUniProtKB
RNA phosphodiester bond hydrolysis, exonucleolyticdefinition[GO:0090503]  
1
  • TASGOC
rRNA processingdefinition[GO:0006364]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+23016  
According to Reactome, this protein belongs to the following pathways:
ATF4 activates genes  REACT_18355  
Butyrate Response Factor 1 (BRF1) destabilizes mRNA  REACT_24915  
KSRP destabilizes mRNA  REACT_25042  
mRNA decay by 3' to 5' exoribonuclease  REACT_20619  
Tristetraprolin (TTP) destabilizes mRNA  REACT_25064  
Caution 
The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active.  
  • CuratedUniProtKB
 

Keywords

Biological process 
rRNA processing  definition   [KW-0698]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23016
PRO: PR:Q15024