ACAP1 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 - human protein (Function)
 
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ACAP1 »  Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
 
Protein also known as:  Centaurin-beta-1 (Cnt-b1).
Gene name:  ACAP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.  
5
  • CuratedUniProtKB
GO molecular function 
ARF GTPase activator activitydefinition[GO:0008060] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Regulation of ARF GTPase activitydefinition[GO:0032312] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
It is regulated in the following manner
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocytosis  hsa04144+9744  
Note 
Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CENTB1
GenomeRNAi: 9744
PRO: PR:Q15027