LARS2 - Probable leucine--tRNA ligase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
LARS2 »  Probable leucine--tRNA ligase, mitochondrial   [ EC 6.1.1.4 ]
 
Protein also known as:  Leucyl-tRNA synthetase (LeuRS).
Gene name:  LARS2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Aminoacyl-tRNA editing activitydefinition[GO:0002161] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Leucine-tRNA ligase activitydefinition[GO:0004823]  
  • IEAEC 2 GO
GO biological process 
Leucyl-tRNA aminoacylationdefinition[GO:0006429] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.4: ATP + L-leucine + tRNA(Leu) AMP + diphosphate + L-leucyl-tRNA(Leu).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+23395  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q15031
Other
GeneWiki: LARS2
GenomeRNAi: 23395
PRO: PR:Q15031