TRAM2 - Translocating chain-associated membrane protein 2 - human protein (Function)
 
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TRAM2 »  Translocating chain-associated membrane protein 2
 
Gene name:  TRAM2
Family name: TRAM
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Collagen biosynthetic processdefinition[GO:0032964]  
1
  • IMPUniProtKB
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Translocation  definition   [KW-0811]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRAM2
GenomeRNAi: 9697
PRO: PR:Q15035