JOSD1 - Josephin-1 - human protein (Function)
 
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JOSD1 »  Josephin-1   [ EC 3.4.19.12 ]
 
Protein also known as:  Josephin domain-containing protein 1.
Gene name:  JOSD1
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.  
2
  • CuratedUniProtKB
GO molecular function 
Omega peptidase activitydefinition[GO:0008242] silver  
  • IEAInterPro 2 GO
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
2
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9929
PRO: PR:Q15040